Understanding the characteristics of the host genome and microbiome interaction in oral squamous cell carcinoma: a narrative review

Abstract Background Oral health status is directly associated with microbes present within it. The abundance of at the OSCC site more than its control site, representing possible role in progression development. Dysbiosis oral microbiota could be a crucial etiological risk factor elevation OSCC. This study aimed to analyze and assess: a) positive regulator cancer their b) pathways involved microbes, c) identification most virulent oncogenic microbe. Main body It obtained from several studies that belonging Prevotella, Fusobacterium, Alloprevotella, Capnocytophaga, Porphyromonas, Campylobacter, Aggregatibacter are detected number contrast healthy s. Fusobacterium nucleatum, Porphyromonas gingivalis, Candida albicans show molecular linked Genes encoding for factors like FimA, Gingipains, lipopolysaccharide ( P. gingivalis) , FadA, Fap2 F. nucleatum ), zymosan C. Albicans ) elevating cancer. Conclusion Mostly, genes promoting generally encode cell wall proteins. proteins Fap, FimA interact host's hamper normal regulation pathway, which leads activation proliferating pathways, down-regulates apoptotic cytoskeleton rearrangement, upregulates cycle checkpoint regulators; as result, occurs.